Multi-beat right ventricular–pulmonary arterial coupling and survival in pulmonary hypertension: are we missing the right signals?
Abstract
Extract In their article published in this issue of the European Respiratory Journal, Rosen et al. [1] elegantly demonstrated that multi-beat pressure–volume loop-derived right ventricular–pulmonary arterial (RV–PA) coupling predicts transplant-free survival in patients with pulmonary arterial hypertension (PAH). Their findings reinforce the growing recognition that RV–PA coupling is a physiologically grounded and robust marker of disease severity and clinical worsening and – as first described by our group, to the best of our knowledge, and in the largest well-characterised PAH-only cohort reported so far – also of survival, thereby potentially complementing the traditional haemodynamic indices used for risk stratification [2–4].
Fields of Study & Subjects
Pulmonary Hypertension Research and Treatments
Cardiovascular Function and Risk Factors
Cardiovascular Health and Disease Prevention
Publication details
- Journal / source
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Volume
- 67
- Issue
- 1
- Pages
- 2502501–2502501
- Publication date
- 1 January 2026
- Language
- EN