Whether emphysema is centrilobular or panlobular determines pulmonary artery remodelling in COPD

ERJ Open Research 2026 Open access

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Authors: Graziella Turato, Erica Bazzan, Simonetta Baraldo, Mariaenrica Tinè, Umberto Semenzato, Giorgia Puddu, Davide Biondini, Marina P. Saetta, Manuel G. Cosío
DOI: 10.1183/23120541.00961-2025
Cited by: 0
References: 14

Abstract

Extract Emphysema, along with small airway diseases, is a crucial component of COPD. Although the type of emphysema smokers develop is not usually considered, two emphysema types with distinct morphological and physiological characteristics might be present in COPD: centrilobular emphysema (CLE), in which the center of the acinus-respiratory bronchiole and alveolar duct are destroyed with preservation of alveoli, and panlobular emphysema (PLE), seen with α-1 antitrypsin deficiency, but also in smokers with normal levels of the protein [1]. In PLE the whole acinus-respiratory bronchioles and alveoli are destroyed [2].

Fields of Study & Subjects

Chronic Obstructive Pulmonary Disease (COPD) Research Pulmonary Hypertension Research and Treatments Asthma and respiratory diseases

Publication details

Journal / source
ERJ Open Research
Volume
12
Issue
3
Pages
00961–2025
Publication date
6 March 2026
Language
EN