Characteristics of severe disease in granulomatous lymphocytic interstitial lung disease: a retrospective cohort study

ERJ Open Research 2026 Open access

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Authors: Kale S. Bongers, Angeline Massett, Smita V. Patel, Kristine E. Konopka, Vivek Nagaraja, Bonnie Wang, Anna Kovalszki, David N. O’Dwyer
DOI: 10.1183/23120541.01617-2025
Cited by: 0
References: 17

Abstract

Extract Common variable immunodeficiency (CVID) is an immunodeficiency disorder characterized by reduced immunoglobulin levels, attenuated antibody responses, and infections. [1–3] CVID patients are also at risk for granulomatous lymphocytic interstitial lung disease (GL-ILD), an interstitial lung disease with lymphocytic infiltrate and/or granulomatous inflammation where other causes have been excluded. [4] Risk factors for severe GL-ILD remain poorly understood, limited by its heterogeneity and rarity. [5] We performed a single-center retrospective cohort study to identify severe disease characteristics.

Fields of Study & Subjects

Immunodeficiency and Autoimmune Disorders Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Transplantation: Methods and Outcomes

Publication details

Journal / source
ERJ Open Research
Volume
12
Issue
4
Pages
01617–2025
Publication date
16 February 2026
Language
EN