Oesophageal functional phenotypes in refractory gastro-oesophageal reflux disease-related chronic cough

ERJ Open Research 2026 Open access

Read full text
Authors: Yoshihiro Kanemitsu, Eiji Kubota, Keima Ito, Yuta Mori, Kensuke Fukumitsu, Satoshi Fukuda, Tomoko Tajiri, Hirotsugu Ohkubo, H KATAOKA, Akio Niimi
DOI: 10.1183/23120541.01746-2025
Cited by: 0
References: 15

Abstract

Extract Gastroesophageal reflux disease (GERD) has been increasingly recognized as a cause of chronic cough (CC) in Japan [1]. While proton pump inhibitors (PPIs) are commonly prescribed to diagnose and treat GERD-associated chronic cough (GERC), some patients exhibit refractory responses to some specific treatments [1]. Emerging evidence indicates that the pathogenesis of refractory-GERC (R-GERC) is significantly affected by non-acid reflux, esophageal mucosal injury, and esophageal dysmotility [2, 3]. However, the relationship between esophageal functional characteristics and cough-related outcomes in patients with R-GERC remains poorly comprehended.

Fields of Study & Subjects

Gastroesophageal reflux and treatments Respiratory and Cough-Related Research Gastrointestinal motility and disorders

Publication details

Journal / source
ERJ Open Research
Volume
12
Issue
3
Pages
01746–2025
Publication date
30 January 2026
Language
EN