Quantum dot enhanced photonic biosensors for single cell analysis from synthesis to clinical application
Abstract
The quantum dot (QD)-enhanced optical biosensors are very sensitive tools for analyzing single cells. Heavy metal-free alternatives, such as indium phosphide and carbon-based QDs, address safety concerns while achieving high quantum efficiency. Photonic enhancement techniques provide 240-fold signal amplification and quality factors of up to 7000, allowing femtomolar detection limits. However, clinical translation encounters manufacturing scalability and stability problems in complex biological matrices. This review discusses synthetic techniques, surface functionalization, and clinical implementation, highlighting important challenges and potential for improving QD-based biosensors.
Fields of Study & Subjects
Carbon and Quantum Dots Applications
Biosensors and Analytical Detection
Quantum Dots Synthesis And Properties
Publication details
- Journal / source
- Discover Nano
- Publisher
- Springer Science and Business Media LLC
- Volume
- 21
- Issue
- 1
- Publication date
- 24 February 2026
- Language
- EN