The role of CAR and SII values in determining mortality in COVID-19 patients: a retrospective observational study

AIM: This study aimed to determine the relationship between CAR, SII and mortality in patients with coronavirus disease (COVID-19). METHODS: This retrospective study included COVID-19 patients admitted to the emergency department (ED) of a secondary unit care hospital. The relationship between the laboratory parameters (Neutrophil-lymphocyte ratio (NLR) and Platelete-lymphocyte ratio (PLR), fibrinogen, D-dimer, procalcitonin, ferritin, and C-reactive protein, blood urea nitrogen (BUN), creatinine (Crea)), and COVID-19 mortality was examined by comparison with the survival group. Logistic regression analysis was performed to investigate the independent factors affecting mortality. RESULTS: A total of 1519 COVID-19 patients were analyzed. Mortality was observed in 799 patients (52.6%), and survival was observed in799 patients (52.6%). Neutrophil-lymphocyte ratio (NLR) and Platelete-lymphocyte ratio (PLR) averages were found to be higher and more significant in the mortality group compared to the survival group (p < 0.001). The levels of fibrinogen, D-dimer, procalcitonin, ferritin, and C-reactive protein (CRP), which are acute-phase reactants, were found to be higher and statistically significant in the mortality group than in the survival group (p < 0.001), and blood urea nitrogen (BUN), creatinine (Crea), aspartate aminotransferase (AST), and C-reactive protein (CRP) were found to be independent factors affecting mortality in patients with COVID-19 (p < 0.05). CONCLUSIONS: SII and CAR cannot be used as independent predictors of mortality in COVID-19 patients.