Trends in mortality among patients with malignant neoplasm of kidney in the United States, 1999–2023: a retrospective study

BACKGROUND: This study aims to identify trends in malignant neoplasm of kidney -related mortality in the United States from 1999 to 2023, and examine variations in these trends by sex, race, and region. METHODS: Age-adjusted mortality rates (AAMRs) and crude death rates (CDRs) per 100,000 by sex, race/ethnicity, age group, and geographic regions were used. AAMRs and CDRs were analyzed using the Joinpoint Regression Program to calculate annual percentage changes (APCs) and average APCs (AAPCs). RESULTS: Between 1999 and 2023, male individuals exhibited higher mortality rates due to malignant neoplasms of the kidney compared to their female counterparts. When analyzed by race and ethnicity, Black patients recorded the highest age-adjusted mortality rate (AAMR) throughout the study period, reaching 6.38 per 100,000 individuals in 1999. Moreover, AAMRs were consistently elevated in rural regions compared to urban settings. Regarding age demographics, individuals aged 85 and older experienced the highest overall crude mortality rate of 31.05 per 100,000 individuals in 1999. In contrast, the lowest rate was observed in the 25–34 age group, at 0.13 per 100,000 individuals during the same year. Additionally, significant regional disparities in mortality rates were observed across the Midwest, Northeast, and Western regions. CONCLUSION: Significant sociodemographic disparities exist in the mortality trends of malignant neoplasm of kidney in the United States. These findings highlight the need for targeted interventions and further research to address these disparities and improve outcomes for all populations affected by malignant neoplasm of kidney.