Outcomes after biologic initiation among patients with severe asthma and normal lung function in the CHRONICLE study

Respiratory Research 2026 Open access

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Authors: Reynold A. Panettieri, Arjun Mohan, Njira Lucia Lugogo, Dennis K. Ledford, Donna D. Carstens, Christopher S. Ambrose
DOI: 10.1186/s12931-025-03439-8
Cited by: 0
References: 8

Abstract

A subset of patients with severe asthma (SA) has normal lung function, defined by a pre-bronchodilator (BD) forced expiratory volume in 1 second (FEV 1 ) of ≥80% of predicted normal value. The effect of biologic treatments on patients with SA and normal lung function is not well understood. This analysis assessed the effectiveness of biologics among adults with SA and normal lung function using data from CHRONICLE (NCT03373045), a real-world observational study of United States patients with SA. Among the 233 patients in this analysis, 28.8% ( n =67) had normal lung function, whereas 71.2% ( n =166) had reduced lung function (pre-BD FEV 1

Fields of Study & Subjects

Asthma and respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) Research Delphi Technique in Research

Publication details

Journal / source
Respiratory Research
Volume
27
Issue
1
Pages
5–5
Publication date
7 January 2026
Language
EN