Clinical value analysis of long non-coding RNA PVT1 in the diagnosis and prognosis, of acute myocardial infarction with arrhythmia

BACKGROUND: To investigate the diagnostic and prognostic markers for acute myocardial infarction (AMI) complicated by arrhythmia, focusing on the role of the long non-coding RNA PVT1. METHODS: The study cohort included 144 AMI patients with arrhythmia and 153 without. The primary outcome was the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) during the 21d early rehabilitation nursing intervention. PVT1 expression levels were measured using RT-PCR. The diagnostic value of PVT1 was performed by the receiver operating characteristic (ROC) curve. Kaplan-Meier (KM) curve evaluated the prognostic value of PVT1 for MACCE. RESULTS: PVT1 expression was significantly higher in AMI patients with arrhythmia. ROC curve analysis showed that PVT1 had a high value (sensitivity = 78.5%, specificity = 75.2%, AUC = 0.843) for diagnosing AMI with arrhythmia. KM analysis indicated poorer survival outcomes in patients with higher PVT1 expression (Log-rank test, P < 0.001). Cox regression analysis identified low LVEF (HR = 2.764, 95%CI = 1.127–6.780) and high PVT1 (HR = 3.802, 95%CI = 1.054–13.709) as independent risk factors for poor prognosis. CONCLUSIONS: PVT1 is upregulated in AMI patients with arrhythmia and is associated with poor prognosis. PVT1 may serve as a promising diagnostic and prognostic marker for AMI complicated by arrhythmia.