Elevated serum zonulin is associated with high attack frequency in hereditary angioedema: providing insight into the gut–angioedema axis

Orphanet Journal of Rare Diseases 2026 Open access

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Authors: Ragıp Fatih Kural, Kasım Okan, Onurcan YILDIRIM, Elif Azarsız, Serpil Akten, Reyhan Gumusburun, Ceyda Tunakan Dalgıç, Nihal Mete Gokmen
DOI: 10.1186/s13023-026-04286-6
Cited by: 1
References: 37

Abstract

BACKGROUND: Zonulin is a key regulator of epithelial barrier permeability and has been implicated in barrier dysfunction across various inflammatory conditions. To elucidate the potential role of intestinal permeability in HAE, this study investigated serum zonulin levels and evaluated their association with disease activity and psychiatric status. PATIENTS AND METHODS: The study included 28 patients with HAE type 1 (HAE-C1INH) and 30 age- and sex-matched healthy controls. Serum zonulin levels were measured by ELISA. Patients were stratified according to attack frequency (high: ≥2 vs. low:

Fields of Study & Subjects

Coagulation Bradykinin Polyphosphates and Angioedema Barrier Structure and Function Studies S100 Proteins and Annexins

Publication details

Journal / source
Orphanet Journal of Rare Diseases
Publisher
Springer Science and Business Media LLC
Volume
21
Issue
1
Publication date
25 February 2026
Language
EN