PU.1: the conductor of Alzheimer’s symphony
Abstract
A recent study by Ayata et al. (2025) reveals that the transcription factor PU.1 acts as a molecular switch that determines whether microglia protect against or worsen Alzheimer’s disease pathology, with lower PU.1 levels promoting beneficial microglial states that reduce amyloid burden and neuroinflammation.
Fields of Study & Subjects
Music Therapy and Health
Neuroscience and Music Perception
Diverse Music Education Insights
Publication details
- Journal / source
- Molecular Neurodegeneration
- Publisher
- Springer Science and Business Media LLC
- Volume
- 21
- Issue
- 1
- Publication date
- 13 March 2026
- Language
- EN