A reappraisal of APOE genetic effects on Alzheimer’s disease risk in the Japanese population: a meta-analysis

Molecular Neurodegeneration 2026 Open access

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Authors: Akinori Miyashita, Norikazu Hara, Ai Obinata, Tamao Tsukie, Mai Hasegawa, Takanobu Ishiguro, Kensaku Kasuga, Masataka Kikuchi, Tadafumi Hashimoto, Takahisa Kanekiyo, Takeshi Ikeuchi
DOI: 10.1186/s13024-026-00963-z
Cited by: 1
References: 15

Abstract

Our meta-analysis demonstrates that the risk effect of APOE-e4*4 relative to APOE-e3*3 for Alzheimer's disease in the Japanese population is approximately 12-15-fold, comparable to that reported in Caucasian populations, rather than greater than 20-fold as previously reported.

Fields of Study & Subjects

Alzheimer's disease research and treatments Renin-Angiotensin System Studies Genetic Associations and Epidemiology

Publication details

Journal / source
Molecular Neurodegeneration
Publisher
Springer Science and Business Media LLC
Volume
21
Issue
1
Publication date
24 June 2026
Language
EN