Hidden in plain sight: illuminating the tRNA landscape by sequencing
Abstract
Transfer RNAs (tRNAs) are essential for decoding mRNAs into proteins and are increasingly recognized as dynamic regulators of gene expression. Their function is shaped by intricate layers of post-transcriptional processing, modification, aminoacylation, and fragmentation, all of which have been implicated in human disease. Recent advances in high-throughput sequencing have transformed our ability to profile tRNAs and their associated modifications, uncovering their roles in cancer, neuronal function, immune response, and stress response. In this review, we summarize emerging tRNA sequencing technologies and highlight how these approaches reveal fundamental insights into tRNA regulation and its therapeutic potential.
Fields of Study & Subjects
RNA modifications and cancer
RNA and protein synthesis mechanisms
Ubiquitin and proteasome pathways
Publication details
- Journal / source
- Genome biology
- Publisher
- Springer Science and Business Media LLC
- Volume
- 27
- Issue
- 1
- Publication date
- 13 February 2026
- Language
- EN