Blood proteomics: insights from public data

Genome biology 2026 Open access

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Authors: A. Larrea, Chengxin Dai, Alejandro J. Brenes, Kathrin Korff, Benjamin A. Neely, Philipp E. Geyer, Laura F. Dagley, Richard D. Unwin, Alexandra Naba, Michael J. MacCoss, Tiannan Guo, Eric W. Deutsch
+3 more Cesar Martin, Jochen M. Schwenk, Yasset Perez-Riverol
DOI: 10.1186/s13059-026-04027-9
Cited by: 3
References: 86

Abstract

The circulating blood proteome comprises soluble and cellular components that reflect physiological and pathological states across tissues. Advances in mass spectrometry and affinity-based proteomics have improved sensitivity and throughput, enabling the generation of public blood proteomics resources. However, comprehensive assessments of these datasets remain limited. This work reviews the cellular and molecular complexity of publicly available blood proteomics data, recent methodological developments, and the complementarity of diverse data sources across the abundance range, while outlining remaining challenges for translating blood proteomics into personalized medicine.

Fields of Study & Subjects

Advanced Proteomics Techniques and Applications Advanced Biosensing Techniques and Applications Single-cell and spatial transcriptomics

Publication details

Journal / source
Genome biology
Publisher
Springer Science and Business Media LLC
Volume
27
Issue
1
Publication date
12 March 2026
Language
EN