Organelle-specific regulation of ferroptosis

Biology Direct 2026 Open access

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Authors: Yu Shrike Zhang, Mengyan Liu, Min Li, Yile Wu, Mi Xie, Xiaohu Liu, Haodong Lu, Xiaoyan Zhai, Yanling Yang
DOI: 10.1186/s13062-025-00717-9
Cited by: 3
References: 253

Abstract

Ferroptosis, an iron-dependent form of regulatory cell death driven by lipid peroxidation, has emerged as a key factor in several pathological conditions. At the organelle level, ferroptosis involves complex interactions between mitochondria, lysosome, endoplasmic reticulum (ER), Golgi apparatus, Nucleus, autophagosome, lipid droplet and peroxisome. Each of them plays a unique role in the ferroptosis cascade. Although the molecular mechanisms of ferroptosis have been extensively studied, the role of specific organelles in this process has not been fully explored. This review aims to summarize the latest advances in organelle-level changes during ferroptosis.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Trace Elements in Health Iron Metabolism and Disorders

Publication details

Journal / source
Biology Direct
Publisher
Springer Science and Business Media LLC
Volume
21
Issue
1
Pages
12–12
Publication date
2 January 2026
Language
EN