Construction and validation of a nomogram to predict sequential oxygen therapy following extubation from invasive mechanical ventilation in patients undergoing coronary artery bypass grafting: a retrospective study

OBJECTIVE: This study developed a predictive model to identify the high-risk patients for sequential oxygen therapy (SOT) following the extubation from invasive mechanical ventilation (IMV) in patients with coronary artery bypass grafting (CABG). RESULTS: A total of 152 patients were included in this study. Both univariate and multivariate logistic regression analyses identified the potential risk factors associated with the need for SOT following the extubation from IMV in patients with CABG, including the timing of endotracheal extubation (OR = 0.40, 95%CI = 0.29-0.52), duration of IMV (OR = 7.37, 95%CI = 4.28-10.47), simple/combined CABG (OR = 4.31, 95%CI = 1.95-6.67), 1-hour postoperative creatine kinase (CK) levels (OR = 1.60, 95%CI = 1.17-2.02), oxygenation index (OI) (OR = 0.74, 95%CI = 0.63-0.85), and base excess (BE) (OR = 0.47, 95%CI = 0.36-0.57) at the time of extubation. The nomogram demonstrated a consistency index (C-index) and an area under the ROC curve of 0.700. The calibration curve indicated a high degree of agreement between predicted and observed values, and the DCA confirmed the practical utility of the identified indicators.