Comparative analysis of four sequencing platforms for methylation sequencing

BMC Research Notes 2026 Open access

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Authors: Jinxia Guan, Chuanchun Yang, Hongjun Gao, Shuanping Liu, Min Zheng, Yongjun Li, Baochen Du, Changling Zhang, Yuanyuan Guo, Qi Wang, Luyang Zhao, XiaoLiang Han
DOI: 10.1186/s13104-026-07690-0
Cited by: 0
References: 12

Abstract

This study conducts a comprehensive assessment of four sequencing platforms: GenoLab M (Genemind), NovaSeq X (Illumina), T7 (MGI) and Salus Pro (Salus), focusing on different performance metrics related to methylation data. By analyzing data from plasma cfDNA samples, we assessed key metrics including sequencing quality, CpG coverage, data efficiency, and methylation level consistency. These findings aim to provide valuable insights into the consistency of sequencing platforms for researchers and laboratories when integrating multiple methylation datasets for analysis.

Fields of Study & Subjects

Epigenetics and DNA Methylation Genomics and Phylogenetic Studies Cancer Genomics and Diagnostics

Publication details

Journal / source
BMC Research Notes
Volume
19
Issue
1
Publication date
16 February 2026
Language
EN