A simple, ligand-free Cu(OH)2-catalyzed methoxylation of aryl halides
Abstract
OBJECTIVE: To develop a simple, rapid and cheap catalytic method for methoxylation of aryl halides for late-stage functionalization and demonstrate its utility in isotopic labelling. RESULTS: A ligand-free, microwave-assisted method for methoxylation of aryl halides using copper(II) hydroxide as catalyst has been explored. The new method is simple and cheap, afforded synthetically useful yields in some cases, but does not seem to give generally higher yields in more substituted systems. The viability of isotopic labelling using the method has been demonstrated by 13C-incorporation at the methoxy group.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- BMC Research Notes
- Volume
- 19
- Issue
- 1
- Publication date
- 14 February 2026
- Language
- EN