Associations of inflammatory biomarkers with brain atrophy and clinical scores in schizophrenia patients with autistic features

BMC Research Notes 2026 Open access

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Authors: Jin Wang, Jie Shen, Yu Tao Pang, Jihui Liu, Lili Zhao, Momo Sun, Yang Yang
DOI: 10.1186/s13104-026-07746-1
Cited by: 0
References: 22

Abstract

Abstract Objectives : This study explored the schizophrenia (SCZ) patients with autistic traits by analyzing inflammatory biomarkers and brain atrophy (BA). Methods : The statistical analysis included 58 males and 55 females. All the subjects underwent computed tomography (CT) and laboratory analysis. SCZ symptom was assessed via the Positive and Negative Syndrome Scale (PANSS). The PANSS Autism Severity Score (PAUSS) was used to assess autistic traits, with a threshold of 30 to identify relevant characteristics. Results : Multiple regression analysis revealed significant associations between positive scores and lymphocyte count (LYM) ,platelet-to-lymphocyte ratio (PLR) , and the minimum width of the anterior horn of the lateral ventricle (WMIN-AH-LV) ( P

Fields of Study & Subjects

Tryptophan and brain disorders Stress Responses and Cortisol Neuroendocrine regulation and behavior

Publication details

Journal / source
BMC Research Notes
Publisher
Springer Science and Business Media LLC
Volume
19
Issue
1
Publication date
10 April 2026
Language
EN