A new strategy for inflammatory regulation in sepsis: mechanisms and clinical progress of hemoperfusion techniques in correcting inflammatory homeostasis in sepsis

Sepsis has a high global morbidity and mortality rate. Its pathophysiological mechanisms are complex and can also adversely affect the function of multiple organ systems. Inflammation plays a crucial role in the development of sepsis. Early intervention and blockage of the inflammatory cascade in septic patients can improve their hemodynamics, remodel the homeostasis of the body's internal environment, and improve their prognosis, which has important social and economic benefits for both patients and society. Hemoperfusion combined with continuous renal replacement therapy (CRRT) shows unique advantages in removing inflammatory mediators and improving patients' organ function. This article reviews the pathophysiological mechanisms of sepsis, the application of hemoperfusion technology in septic patients, and recent research progress.