Axonopathy: mechanisms and potential therapeutic targets for neurodegenerative diseases
Abstract
Axons are unique structural and functional features of nerve cells, which play a critical role in regulating neuronal homeostasis. Dysfunction and degeneration of axons (axonopathy) has been established as an early and prominent contributing mechanism to the pathogenesis of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. In this review, we briefly summarize the structure and function of axons, and highlight recent advances in the understanding of the role of axons in health and disease. We argue that axons are a potential target for developing novel therapies for neurodegenerative diseases.
Fields of Study & Subjects
Axon Guidance and Neuronal Signaling
Nerve injury and regeneration
Sirtuins and Resveratrol in Medicine
Publication details
- Journal / source
- Translational Neurodegeneration
- Publisher
- Springer Science and Business Media LLC
- Volume
- 15
- Issue
- 1
- Publication date
- 24 March 2026
- Language
- EN