SOFA-2 versus SOFA-1 for mortality prediction in critically ill patients

Journal of Intensive Care 2026 Open access

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Authors: Songjie Bai, Meiling Huang, Hui Chen, Xinyi Yang, Lin Chen, Fen Liu, Xuehuan Wen
DOI: 10.1186/s40560-026-00875-6
Cited by: 2
References: 5

Abstract

We validated the SOFA-2 score against the SOFA-1 score using 65,366 critically ill patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. SOFA-2 demonstrated superior discrimination for ICU mortality (AUROC: 0.829 [95% CI 0.823-0.835] vs. 0.796 [0.789-0.803]) and in-hospital mortality (0.789 [0.783-0.794] vs. 0.763 [0.757-0.769]) compared with SOFA-1. Of 65,366 patients, 40,990 (62.7%) were reclassified to higher scores under SOFA-2. Within each SOFA-1 stratum, those assigned higher SOFA-2 scores consistently demonstrated higher ICU mortality, confirming clinically meaningful reclassification. These findings provide additional external validation supporting the advantages of SOFA-2 for risk stratification in critically ill patients.

Fields of Study & Subjects

Sepsis Diagnosis and Treatment S100 Proteins and Annexins Cardiac Anesthesia and Surgical Outcomes

Publication details

Journal / source
Journal of Intensive Care
Publisher
Springer Science and Business Media LLC
Volume
14
Issue
1
Publication date
24 March 2026
Language
EN