Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant

Journal of Clinical Oncology 2026

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Authors: Nicole Liberio, Mariam Allbee-Johnson, Kwang Woo Ahn, Amy Moskop, Rachel Phelan, Bronwen E. Shaw, Kristin Page, Kirk R. Schultz, Christine L. Phillips, Parinda A. Mehta, Muna Qayed, Akshay Sharma
+9 more Amanda E. Lipsitt, Heather J. Symons, Javier Bolaños-Meade, Sandhya Kharbanda, Christopher C. Dvorak, Neena Kapoor, Erin Doherty, Rishikesh Chavan, Larisa Broglie
DOI: 10.1200/jco-25-01591
Cited by: 2
References: 29

Abstract

PURPOSE: Critical guidance on selecting haploidentical donors for pediatric patients is lacking. It is unclear whether parents, siblings, and extended family affect acute and chronic graft-versus-host disease (aGVHD and cGVHD) differently. METHODS: We analyzed 1,069 pediatric (35 years, HR, 2.53 [95% CI, 1.46 to 4.41]; mothers 18-35 years, HR, 2.05 [95% CI, 1.14 to 3.69]) (cGVHD: mothers >35 years, HR, 3.10 [95% CI, 1.72 to 5.60]; mothers 18-35 years, HR, 3.35 [95% CI, 1.8 to 6.25]). CONCLUSION: Donors

Fields of Study & Subjects

Hematopoietic Stem Cell Transplantation Acute Lymphoblastic Leukemia research Immunodeficiency and Autoimmune Disorders

Publication details

Journal / source
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Volume
44
Issue
11
Pages
1003–1015
Publication date
25 February 2026
Language
EN