SUPPORT+ digital self-management and clinical support for advanced cancer: A randomized controlled trial.

LBA12008 Background: Patients with advanced cancer often experience distressing symptoms that impair HRQoL and lead to emergency department (ED) visits and hospitalizations. Digital symptom-monitoring tools enable earlier detection of symptoms, yet evidence in palliative care remains limited. This study evaluated whether SUPPORT+, a mobile app incorporating weekly symptom reporting using the Integrated Palliative Care Outcome Scale (IPOS), automated self-management guidance, and nurse follow-up for severe symptoms, improves outcomes when added to usual care for community-dwelling patients with advanced cancer. Methods: A multi-centre RCT was conducted across 6 palliative care clinics in Hong Kong (Jan 2023–Feb 2025). Patients with advanced cancers no longer receiving systemic treatment were randomized 1:1 to SUPPORT+ or usual care for 18 weeks. The primary outcome was change in HRQoL (EQ-5D-5L). Secondary outcomes included ECOG PS, ED visits, and hospitalizations. Results: A total of 633 patients were enrolled (315 intervention; 318 control), median age 79 (range 31–103), with 47.4% male. HRQoL was better maintained in SUPPORT+: EQ-5D-5L index declined from 0.59 at baseline to 0.52 at week 18 vs. 0.62 to 0.37 in usual care (mean difference −0.18; p