Total gastrectomy (TG) versus distal gastrectomy (DG) for distal diffuse gastric cancer (GC).

305 Background: Diffuse gastric cancer (GC) in advanced stages has a poor prognosis. There is no clear consensus regarding the extent of surgical procedure for distal diffuse GC. Most surgeons prefer to perform total gastrectomy (TG) to achieve more radicality and reduce a local recurrence rate. Perhaps, the distal gastrectomy (DG) is not worse in terms of survival rates in distal diffuse GC compared with TG. Methods: The retrospective analysis was undertaken of 125 patients with distal diffuse gastric cancer. These patients received TG or DG at the N.N. Blokhin National Medical Research Center of Oncology in period from January 2005 to December 2022. We compared clinical, pathological features and survival rates between these groups. Results: Univariate analysis revealed that depth of tumor invasion, lymph nodes status and stage of the disease were associated with OS (p