The Liver Cancer and Frailty in Elderly (LIFE) study: Longitudinal functional status analysis in patients with advanced hepatocellular carcinoma (HCC) and prognostication.
Abstract
521 Background: The incidence of HCC has tripled over recent decades, with a disproportionately higher burden among older adults. Traditional scoring systems such as the Child-Pugh, Model for End-Stage Liver Disease (MELD), and Albumin-Bilirubin (ALBI) scores have been widely adopted to assess hepatic function and predict mortality. While these scores offer valuable insights, they may not fully capture the functional status and quality of life of patients. Therefore, we conducted an analysis of associations between geriatric assessments and prognostic scoring systems. Methods: Data from a prospective observational study (NCT03894917) of 86 patients with advanced HCC were analyzed. Patients were stratified into two categories:
Fields of Study & Subjects
Frailty in Older Adults
Hepatocellular Carcinoma Treatment and Prognosis
Nutrition and Health in Aging
Publication details
- Journal / source
- Journal of Clinical Oncology
- Volume
- 44
- Issue
- 2_suppl
- Pages
- 521–521
- Publication date
- 10 January 2026
- Language
- EN