The Liver Cancer and Frailty in Elderly (LIFE) study: Understanding longitudinal functional status in patients with advanced hepatocellular carcinoma (HCC) and aspartate aminotransferase-to-platelet ratio index (APRI).

527 Background: Hepatocellular carcinoma (HCC) is a significant contributor to cancer related mortality and morbidity in older adults. Geriatric assessments, such as Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL), offer unique opportunity to evaluate vulnerability of patients with HCC, but their longitudinal relationship to liver-specific biomarkers remains underexplored. The aspartate aminotransferase-to-platelet ratio index (APRI), a widely used surrogate for hepatic fibrosis, may complement these assessments by capturing fibrosis-related functional decline. Our study aims to explore the relationship between APRI and ADL/IADL. Methods: Data from a prospective observational study (NCT03894917) of 80 patients with advanced HCC were analyzed. Self-reported assessments of basic activities of daily living (ADL) and instrumental activities of daily living (IADL) were evaluated at baseline, 2, 4, and 6 months, comparing patients aged