Clinicopathologic features and overall survival of patients with early-onset colorectal cancer in a South African cohort study.

Journal of Clinical Oncology 2026

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Authors: Jacob Lee Dubner, Brendan Bebington, June J Fabian, Lisa J. Campbell, Clement Brian Penny, Leanne M. Prodehl, Thomas Kekgatleope Marumo, Damon Bezos, Daniel Surridge, C Jann-Kruger, Paul Ruff, Yoanna S Pumpalova
DOI: 10.1200/jco.2026.44.2_suppl.58
Cited by: 0

Abstract

58 Background: The incidence of early-onset colorectal cancer (EOCRC) has increased across sub-Saharan Africa, but data describing the features of EOCRC in this region is limited. We characterized the demographics, clinicopathologic features, and survival outcomes of EOCRC patients in South Africa (SA). Methods: The Colorectal Cancer in South Africa (CRCSA) study is a longitudinal cohort study that enrolled CRC patients from five academic teaching hospitals affiliated with the University of the Witwatersrand between 2016 and 2019. We excluded patients with known mismatch repair deficiency and treated patients with multiple primary tumors as distinct cases. We stratified the cohort by age at CRC diagnosis (

Fields of Study & Subjects

Colorectal Cancer Screening and Detection Colorectal Cancer Surgical Treatments Genetic factors in colorectal cancer

Publication details

Journal / source
Journal of Clinical Oncology
Volume
44
Issue
2_suppl
Pages
58–58
Publication date
10 January 2026
Language
EN