International and contrasting perspectives on early-onset colorectal cancer: Awareness, testing, and research priorities of survivors and caregivers.

59 Background: Early-onset colorectal cancer (EOCRC) incidence is increasing worldwide, yet little is known about regional patterns in awareness, testing, and clinical trial referral. Methods: We administered, an online cross-sectional survey conducted in May of 2025 and analyzed responses from 400+ EOCRC survivors and caregivers across Europe, North America, and Oceania. Survivor responses were based on their lived experience and caregivers responded based on their experience as a caregiver to an affected CRC young survivor. The survey is now being targeted for further global representations. Respondents reported stage and age at diagnosis, prior knowledge of EOCRC, experiences with genetic/tumor testing, clinical trial recommendations, and research priorities. Regional and survivor–caregiver differences were assessed. Results: Most patients were diagnosed between ages 30–49 and at advanced stages. Among survivors, 44.3% were diagnosed at stage III and 29.7% at stage IV; stage IV diagnosis was most common in North America (40.8%). Caregivers reported even higher late-stage presentation, with 56.3% at stage IV, peaking at 61.1% in Europe. Younger diagnoses (