Longitudinal morphomics and metabolomics as metastatic pancreatic cancer prognosticators.
Abstract
781 Background: Morphomics evaluates patients’ body composition, including subcutaneous fat, visceral fat, muscle, and fascia, from radiologic scans. Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy with few prognosticators. We previously showed baseline morphomics were associated with PDA survival. Here, we study how morphomic variables change over time, are associate with survival, and investigate morphomics and metabolism as potentially modifiable targets to improve patient survival. Methods: Of 528 metastatic PDA patients enrolled on the phase 3 Avenger500 trial, patients without a baseline and follow-up CT scan were removed. To reduce potential effects of reverse causation, patients with
Fields of Study & Subjects
Pancreatic and Hepatic Oncology Research
Radiomics and Machine Learning in Medical Imaging
Body Composition Measurement Techniques
Publication details
- Journal / source
- Journal of Clinical Oncology
- Volume
- 44
- Issue
- 2_suppl
- Pages
- 781–781
- Publication date
- 10 January 2026
- Language
- EN