Beyond Circulating Tumor DNA for Efficacy: Can We Use Cell-Free DNA to Detect and Monitor Toxicity Signals?

JCO Precision Oncology 2026 Open access

Read full text
Authors: Yiqing Zhao, John Gallon, Max H. Kushner, Brad L. Jakubison, Jorge Sergio Reis-Filho, Darren Hodgson, Julia Elvin, Yuval Dor, James Hadfield
DOI: 10.1200/po-26-00178
Cited by: 1
References: 20

Abstract

Recent cell type methylome atlases revealed thousands of differentially methylated regions, 97% of which are unmethylated and typically overlap cell type-specific enhancers, as biomarkers that could be used to quantify cell-specific cfDNA.9,10 These developmentally linked loci appear to be universal across individuals regardless of age, sex, or ethnicity and are

Fields of Study & Subjects

Cancer Genomics and Diagnostics Cancer Cells and Metastasis Advanced biosensing and bioanalysis techniques

Publication details

Journal / source
JCO Precision Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Volume
10
Issue
5
Pages
e2600178–e2600178
Publication date
1 May 2026
Language
EN