Senolytics in Skin Care and Skin Diseases

The skin is the largest but comprehensible organ that responds to several kinds of stimuli. It is an attractive organ to understand senolytic and senomorphic behavior of various agents to combat cellular senescence. Cellular senescence can occur due to apoptosis, replicative arrest, increased reactive oxygen species, metabolic and mitochondrial dysfunction or senescent-associated secretory factors. The traits of senescence can be detected with several factors like chronic inflammation, wound healing, oxidative stress or aging. These factors may cause delayed wound healing, wrinkles, skin sagging, decreased dermal collagen or fibroblast accumulation. Awareness regarding precise skin cells like melanocytes or fibroblasts will improve the understanding of skin-related degeneration and aging. Recent studies have defined the role of senescence in pathology and physiology of the skin. Dermatological research regarding impact of cellular senescence can improve the understanding of beneficial as well as deleterious effects of senotherapy on skin. This chapter presents the mechanisms and factors associated with skin cellular senescence and preclinical and clinical researchers that attempt to focus on agents that can benefit the pathophysiology of skin.