Genomic Insights in Gallbladder Cancer

Gallbladder cancer (GBC), the most common malignant neoplasm of the bile ducts, remains a highly lethal disease due to its asymptomatic nature, late diagnosis, and rapid progression. Recent advances in cancer genomics have shifted focus toward developing molecular profiles based on patient-specific tumor characteristics, paving the way for innovative and personalized therapeutic strategies. GBC exhibits a complex array of genetic alterations, including mutations in key oncogenes that drive carcinogenesis and influence clinical outcomes. This chapter explores the diverse genetic landscape of GBC and highlights how genomic insights are transforming its clinical management by enabling precision medicine approaches aimed at improving prognosis and treatment efficacy.