Therapeutic Potential of Asparagus racemosus in Kidney Diseases

Asparagus racemosus , also known as Shatavari, is found worldwide. It belongs to the family Asparagaceae (Liliaceae). Its roots, leaves, and other parts are dried for medicinal use. This plant contains numerous pharmacologically active compounds, including sapogenins, sarsasapogenins, kaempferol, quercetin, rutin, and others. In Unani and Siddha, it was used in the ancient medical system for the treatment of diabetes, dyspepsia, cough, jaundice, haemorrhage, and lactation promotion. In Ayurveda, it was regarded as a feminine tonic and was used extensively to treat a variety of illnesses, including rheumatism, persistent fevers, conjunctivitis, spasms, inflammation, tumors, bronchitis, neurological disorders, hyperacidity, hepatotoxicity, and several infectious diseases. The incidence of chronic kidney disease (CKD) is increasing worldwide, resulting in a financial and social burden on health systems. Kidney failure, the final stage of CKD, is life-threatening if untreated with kidney replacement therapies. Current therapeutic agents, such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, and calcium channel blockers, generally delay the progression of CKD and are not the ultimate solution for complete treatment. This chapter focuses on the effective uses of Asparagus racemosus and its bioactive components as an alternative approach to the protection of kidney function and delaying the progression of end-stage renal disease. Asparagus racemosus and its bioactive compounds are capable of modulating inflammation, oxidative stress, ROS generation, and structural impairments.