Chronic Wounds: Chitosan-Based Formulations from Lab to Bedside

Chitosan-based biomaterials are highly regarded for their ability to improve wound healing by virtue of their properties of being able to break down naturally, being compatible with living tissue, not causing harm, having the ability to fight against microorganisms, being able to stick to biological surfaces, having biological effects, and promoting blood clotting. Studies have shown that hydrogels made from chitosan can improve the wound-healing process at various stages while also reducing variables that hinder wound healing, such as excess inflammation and infections of chronic wound. A chitosan-based biomaterial’s unique biological properties enable its use as both a drug delivery system (DDS) and as a wound dressing, facilitating the delivery of antibacterial, growth factors, stem cells, and other substances that help wounds heal faster. Hydrogels of chitosan have the abilitytoimprove healing efficiency for avariety of wound types. To achieve this, one can alter or mix them with other polymers and incorporate various active ingredients. This chapter closely examines the use of chitosan-based biomaterials in wound dressings and DDS in improving the healing process. This chapter also provides a detailed examination of the phases and mechanisms, benefits, and drawbacks, as well as insights into future possibilities. It also discusses the preclinical and clinical trials of 3D printing methods and their application in wound healing.