Rodent Models of Prion Disease
Abstract
Rodent models have been indispensable in advancing the understanding of prion diseases, fatal neurodegenerative disorders caused by the misfolding of the cellular prion protein (PrP C ) into the pathogenic isoform PrP Sc . These models have been pivotal in elucidating disease mechanisms, strain variation, species barriers, and routes of neuroinvasion, while also serving as platforms for diagnostic development and therapeutic evaluation.
Fields of Study & Subjects
Prion Diseases and Protein Misfolding
Alzheimer's disease research and treatments
Amyloidosis: Diagnosis
Treatment
Outcomes
Publication details
- Journal / source
- CRC Press eBooks
- Pages
- 99–107
- Publication date
- 5 February 2026
- Language
- EN
- Document type
- Book chapter