A Brief Review on the Role of Various Molecular Targets and Pharmacological Strategies for Diabetic Wound Healing

According to the WHO, diabetes mellitus is a heterogeneous metabolic disorder characterized by hyperglycemia (an elevated blood glucose level of more than 70 mg/dL) and disturbances in the metabolic processes. It is a rapidly spreading global issue with serious social, health, and economic ramifications. Patients with diabetes mellitus experience slower wound healing, which can lead to foot ulcers. A slow wound-healing process can make it more likely that an infection or other complications will arise. White blood cells (WBCs) are unable to function correctly when blood glucose levels are persistently high, and as a result, the body is less able to 260 fight bacteria and heal wounds. Uncontrolled diabetes can also slow blood flow and affect circulation, which makes it more challenging for the body to nourish wounds. As a result, the wounds might not heal at all or only slowly. Patients with diabetes are more susceptible to bacterial infections in wounds. The traditional signs of high blood sugar include lethargy, weight loss, polyuria (frequent urination), and polydipsia (increased thirst).