Silk-Based Protein for Wound Healing and Implantable Drug Delivery

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Authors: Vineet Kumar Rai, Ajit Kumar Mishra, Ivy Saha, Deepak Pradhan, Jitu Halder, Tushar Kanti Rajwar, Priyanka Dash, Chandan Das, Biswakanth Kar, Goutam Ghosh, Goutam Rath
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Abstract

Silk-based proteins have garnered significant attention in recent years for their promising applications in wound healing and implantable drug delivery. Derived from the silkworm, silk offers unique properties, including biocompatibility, biodegradability, and mechanical strength, making it an attractive biomaterial for medical use. In wound healing, silk dressings and scaffolds have demonstrated the ability to create a protective barrier over wounds, promote tissue regeneration, and can be engineered to release bioactive compounds such as growth factors and antimicrobial agents. Furthermore, silk-based materials have shown potential for controlled drug delivery, as their porous structure allows for the sustained release of therapeutic agents, enabling tailored drug release rates to meet specific therapeutic needs. The low immunogenicity of silk reduces the risk of adverse reactions, and its gradual degradation within the body eliminates the need for surgical removal after drug delivery is complete. Despite these promising attributes, extensive testing and regulatory approval processes remain essential to ensure the safety and efficacy of silk-based products for medical applications. As researchers continue to explore and optimize silk-based materials, the potential impact on wound healing and drug delivery in medical practice appears highly encouraging.

Fields of Study & Subjects

Silk-based biomaterials and applications Electrospun Nanofibers in Biomedical Applications Silkworms and Sericulture Research

Publication details

Journal / source
Apple Academic Press eBooks
Pages
293–315
Publication date
12 February 2026
Language
EN
Document type
Book chapter