The Silk Symphony: Microparticulate Systems Orchestrating Drug Delivery Advancements

Silk-based microparticulate systems have emerged as a promising avenue in drug delivery, offering unique advantages such as biocompatibility, sustained release, and controlled drug administration. This chapter provides an in-depth exploration of the evolving landscape of silk-based microparticulate systems in the field of drug delivery. It delves into the properties of silk as a biomaterial, highlighting its biocompatibility, tuneable characteristics, and sustainable sourcing. Various fabrication techniques for silk microparticles are discussed, showcasing the versatility of silk-based drug carriers. A comprehensive overview of applications demonstrates how silk microparticles have been employed for controlled release, targeted therapy, cancer treatment, and vaccine delivery. Recent advances in functionalization, nanocomposites, and silk-derived peptides are also explored, shedding light on the innovative approaches within the field. With a multidisciplinary perspective, this chapter offers valuable insights for researchers, clinicians, and students interested in the latest advancements and applications of silk-based microparticulate systems for drug delivery.