Early pregnancy biomarkers of inflammation and metabolic regulation in polycystic ovary syndrome

The Journal of Clinical Endocrinology & Metabolism 2026 Open access

Read full text
Authors: Simon Alesi, Tamique Mason, Stacey J. Ellery, Kate Rassie, Adriana C H Neven, Yitayeh Belsti, E Jona, Sharleen O’Reilly, David Simmons, Helena Teede, Aya Mousa, IMPACT DIABETES B2B&ME
+26 more David Simmons, William Hague, Helena Teede, Wah Cheung, Christopher Nolan, Michael Peek, Jeff Flack, Mark Mclean, Vincent Wong, Emily Hibbert, Alexandra Kautzky-Willer, Jürgen Harreiter, Helena Backman, EMILY GIANATTI, Arianne Sweeting, Viswanathan Mohan, TOBOGM Study Groups, Sharleen O’Reilly, Helena Teede, Fionnuala McAuliffe, Cristina Campoy, Christy Burden, Helle Terkildsen Maindal, Timothy Skinner, Rachel Laws, Karsten Vrangbæk
DOI: 10.1210/clinem/dgag098
Cited by: 2
References: 41

Abstract

OBJECTIVE: To profile biomarkers of inflammation and metabolic regulation in early pregnancy among women with and without polycystic ovary syndrome (PCOS), and to assess whether these biomarkers influence the relationship between PCOS and adverse maternal or neonatal outcomes. DESIGN: Cross-sectional study with interaction analyses using pooled baseline data from 2 international multicenter clinical trials. SUBJECTS: One hundred and fifty-one pregnant women (at

Fields of Study & Subjects

Ovarian function and disorders Gestational Diabetes Research and Management Reproductive System and Pregnancy

Publication details

Journal / source
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Volume
111
Issue
8
Pages
e1961–e1972
Publication date
6 March 2026
Language
EN