The role of high BMI from infancy forward on clinician-rated pubertal timing in a large US sample

The Journal of Clinical Endocrinology & Metabolism 2026 Open access

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Authors: Ekaterina Sadikova, Julianna Deardorff, Izzuddin M Aris, Elizabeth W. Diemer, Sara Aghaee, Henning Tiemeier, Ai Kubo
DOI: 10.1210/clinem/dgag100
Cited by: 2
References: 46

Abstract

CONTEXT: High childhood adiposity accelerates pubertal timing, particularly in females. However, it is unclear when in childhood intervention is most important. OBJECTIVE: To disentangle the associations of body mass index (BMI) during infancy, early, mid-, and late childhood with pubertal timing. METHODS: We studied 132 452 (46.6% female) full-term singletons born in Kaiser Permanente Northern California affiliated facilities between January 1, 2003 and December 31, 2011. A mediation analysis was used to disentangle how BMI during infancy (

Fields of Study & Subjects

Hypothalamic control of reproductive hormones Birth Development and Health Obesity Physical Activity Diet

Publication details

Journal / source
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Volume
111
Issue
8
Pages
2200–2209
Publication date
11 March 2026
Language
EN