Determinants of quality of life in patients with immune checkpoint inhibitor–induced secondary adrenal insufficiency

The Journal of Clinical Endocrinology & Metabolism 2026

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Authors: Justine S. Herndon, Yana Hleibiehova, Sara J. Achenbach, Alexandra N Bancos, Elizabeth J. Atkinson, Diane Donegan, Irina Bancos
DOI: 10.1210/clinem/dgag219
Cited by: 1
References: 38

Abstract

CONTEXT: Limited data are available on quality of life (QoL) and adrenal crises in patients with immune checkpoint inhibitor-induced secondary adrenal insufficiency (ICI-SAI). OBJECTIVE: To 1) characterize the presentation, management, and outcomes of patients with ICI-SAI; 2) compare outcomes of ICI-SAI with other etiologies of secondary adrenal insufficiency (oSAI); and 3) identify variables associated with QoL and adrenal crisis. METHODS: In this single-center cross-sectional study, adults with ICI-SAI or oSAI (2018-2025) completed questionnaires assessing symptoms, management, adrenal crises, and the Addison disease-specific QoL survey (AddiQoL).Outcomes AddiQoL score and adrenal crisis events. RESULTS: Patients with ICI-SAI (n=109) were older (median age 66 vs 60 years), more often women (59% vs 43%), and more frequently diagnosed within one year of symptom onset (88% vs 42%, P

Fields of Study & Subjects

Adrenal Hormones and Disorders Cancer Immunotherapy and Biomarkers Pituitary Gland Disorders and Treatments

Publication details

Journal / source
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Volume
111
Issue
11
Pages
e2369-e2381
Publication date
28 May 2026
Language
EN