Children's neurodevelopment at school age after hysterosalpingography with iodinated contrast: a cohort study

PURPOSE: Hysterosalpingography (HSG) with iodinated contrast used during fertility work-up can transiently disrupt thyroid function during early neurodevelopment due to the Wolff-Chaikoff effect. We examined neurodevelopmental outcomes in school-aged children conceived after HSG. METHODS: 69 children conceived within 12 weeks after HSG did not differ from the control group. No differences were observed for behaviour or academic performance. Sensitivity analyses did not support confounding by prematurity, low birth weight, maternal smoking during pregnancy, or conception using assisted reproductive technologies. CONCLUSION: Replication in larger, adequately powered cohorts is needed to assess the potential long-term implications of HSG with iodinated contrast for neurodevelopmental outcomes of the offspring.