JAK inhibitors: risks and safety principles
Abstract
Introduction The Janus kinases (JAKs) are protein tyrosine kinases that mediate cellular responses to several cytokines and growth factors, which play a role in immune defence and immune-mediated disease1. By inhibiting JAKs, JAK inhibitors (JAKi) disrupt the inflammatory signalling pathway, dampening the overactive immune response. In the UK, the National Institute for Health and Care […]
Fields of Study & Subjects
Rheumatoid Arthritis Research and Therapies
Pharmacovigilance and Adverse Drug Reactions
Cytokine Signaling Pathways and Interactions
Publication details
- Journal / source
- Pharmaceutical journal/The pharmaceutical journal
- Publication date
- 1 January 2026
- Language
- EN