Correlation of Muscle-fat Ratio with Non-obese Hyperuricaemia and the Predictive Value

Background Non-obese hyperuricaemia has an insidious onset, and anthropometric indicators such as the conventional BMI have limitations in evaluating the risk of developing this disease. Therefore, it is important to find a simple and inexpensive method to identify non-obese hyperuricaemia. Objective To investigate the correlation of muscle-fat ratio (MFR) with non-obese hyperuricaemia and blood uric acid levels and its predictive value. Methods Non-obese adults who participated in physical examinations in the Xiyuan Hospital of China Academy of Chinese Medicine Sciences from 2021 to 2024 were included in this study. The research subjects were divided into those with hyperuricemia and those without hyperuricemia based on whether they had hyperuricemia or not, and the baseline levels of the two groups were compared. The correlation of MFR with the prevalence of hyperuricemia and blood uric acid levels in non-obese people was analyzed by multivariate Logistic regression and multiple linear regression. Interaction tests were conducted according to gender, age, smoking history, alcohol consumption history and previous disease history. The diagnostic and predictive efficacy of MFR in diagnosing non-obese hyperuricaemia was assessed by using receiver operating characteristic (ROC) curves. Results A total of 1 869 non-obese participants were included in this study, including 428 cases of hyperuricaemia, and 1 441 cases of non-hyperuricaemia. After adjusting for confounders, multivariate Logistic regression showed that an elevated MFR was a protective factor for hyperuricaemia (OR=0.02, 95%CI=0.01-0.04, P