Reduced Effect of APOE4 on White Matter Microstructure in an American Indian Community

Neurology Genetics 2026 Open access

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Authors: René Labounek, Matti J. Matheson, Corey A. Strong, Ashley J. Petersen, Annamarie Hill, Ann J. Robertson, Adam Hansen, Adam D. Block, J. Neil Henderson, Igor Nestrašil, Christophe Lenglet, William G. Mantyh
DOI: 10.1212/nxg.0000000000200418
Cited by: 1
References: 50

Abstract

Apolipoprotein E4 (APOE4) is central to Alzheimer disease (AD) personalized medicine, yet its link to AD is highly ancestry-dependent. Emerging evidence suggests an attenuated risk of APOE4 on brain health in American Indian (AI) participants. This study examines white matter microstructure, an early indicator of brain health deterioration, among tribal Elders carrying the APOE4 allele.

Fields of Study & Subjects

Dementia and Cognitive Impairment Research Advanced Neuroimaging Techniques and Applications Alzheimer's disease research and treatments

Publication details

Journal / source
Neurology Genetics
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
12
Issue
4
Pages
e200418–e200418
Publication date
16 July 2026
Language
EN