Aberrant Complement Activation Is a Prominent Feature of Chronic Inflammatory Demyelinating Polyneuropathy

Neurology Neuroimmunology & Neuroinflammation 2026 Open access

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Authors: Frauke Stascheit, Hannah Preßler, Kerstin Stein, Helena F Pernice, Katrin Hahn, Andreas Meisel, Jan D. Lünemann
DOI: 10.1212/nxi.0000000000200542
Cited by: 2
References: 13

Abstract

OBJECTIVES: To comprehensively characterize complement pathway activation in chronic inflammatory demyelinating polyneuropathy (CIDP) and its association with clinical disease features using advanced complement profiling. METHODS: Complement protein levels indicative of classical, lectin, and alternative pathway activation were quantified by multiplex ELISA and compared between 28 patients with typical CIDP, 24 patients with Charcot-Marie Tooth neuropathy (CMT), and 24 demographically matched healthy controls (HD). RESULTS: < 0.001). DISCUSSION: These findings highlight the critical involvement of aberrant complement activation in the pathophysiology of CIDP and provide a rationale for further investigation into targeted complement inhibition as a therapeutic approach.

Fields of Study & Subjects

Peripheral Neuropathies and Disorders Complement system in diseases Multiple Sclerosis Research Studies

Publication details

Journal / source
Neurology Neuroimmunology & Neuroinflammation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
13
Issue
2
Pages
e200542–e200542
Publication date
7 January 2026
Language
EN