Neuroanatomical Correlates of Depressive Symptoms in Early Multiple Sclerosis

Neurology Open Access 2026 Open access

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Authors: Jonadab dos Santos Silva, Francesco La Rosa, Emma Dereskewicz, Sarah Levy, Robin Graney, Nadia Garcia, Julia Galasso, James Sumowski, Erin S. Beck
DOI: 10.1212/wn9.0000000000000050
Cited by: 3
References: 28

Abstract

Depression is common and sometimes debilitating in multiple sclerosis (MS), with a prevalence 2 to 3 times higher than in the general population. While the link between MS and depression is well established, the specific neurobiological mechanisms, particularly in the early stages of the disease, remain incompletely understood. The aim of this study was to investigate the neuroanatomical correlates of depression in early MS and to explore the interplay between lesions, atrophy, and depressive symptoms.

Fields of Study & Subjects

Multiple Sclerosis Research Studies Stress Responses and Cortisol Vagus Nerve Stimulation Research

Publication details

Journal / source
Neurology Open Access
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
2
Issue
1
Publication date
12 January 2026
Language
EN