Retinal Vessel Dysfunction in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Objectives: -mediated microvascular pathology. As retinal health remains underexplored, serial ultra-widefield fluorescein angiography (UW-FA) was used to characterize dynamic vessel dysfunction. Methods: variant loci, and stroke-age associations were analyzed. Results: = 0.64) in patients with CADASIL. Longitudinal analysis showed reduced blood flow and perfusion in the macula and mid-periphery and increased midperipheral permeability (all statistically significant with substantial effect sizes). Neither genotype nor stroke-onset age predicted alterations. Discussion: Serial UW-FA scans detect progressive, region-specific retinal vessel dysfunction in a modest-sized cohort with CADASIL, potentially serving as a surrogate marker for cSVD progression.