Association Between Longitudinal Rate of Change in CSF Biomarkers and Subsequent Tau PET Burden in Early Braak Stages
Abstract
BACKGROUND AND OBJECTIVES: F-MK6240 tau PET measures in early Braak stage subregions. METHODS: ) measures were obtained from CSF collected biennially over a mean of 12.8 years before tau PET acquisition. Linear mixed-effect models examined how previous CSF biomarker levels and rates of change in these measures related to subsequent tau deposition corresponding to Braak stages I and II. RESULTS: over time was not. DISCUSSION: These findings show that tau PET burden in Braak stage I and II subregions is associated with increases in CSF tau and p-tau over time, offering important insights into the relationships among key biomarkers for the diagnosis and staging of AD, although tau PET was collected at only a single time point, limiting inferences about the temporal evolution of PET-CSF relationships.
Fields of Study & Subjects
Medical Imaging Techniques and Applications
Advanced MRI Techniques and Applications
S100 Proteins and Annexins
Publication details
- Journal / source
- Neurology
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 106
- Issue
- 4
- Pages
- e214620–e214620
- Publication date
- 28 January 2026
- Language
- EN